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Deletion of one additional residue (EF-GS construct) abolished the activation of the receptor, yet the receptor can be activated by exogenous EX4 to a comparable level, indicating the receptors were functionally expressed (the expression levels also shown in Supplementary Figure S2A)
They are especially relevant right now, because the FDA issued 30 warning letters to compounded GLP-1 telehealth companies in early 2026, and on April 30, 2026 proposed a rule that would - if finalized - permanently close the large-scale compounding pathway for semaglutide and tirzepatide
GEP44-mediated increases in glucose transport also correlated with its stimulation of lactate production and thus a downstream impact on muscle metabolism
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