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However, this same effect creates the physiological basis for common adverse effects including nausea, vomiting, early satiety, bloating, and belching

Newsome PN, et al

The medication is administered as a once-weekly subcutaneous injection, typically started at a low dose (0.25 mg weekly for diabetes

This occurs because the appetite-suppressing effects of semaglutide cease, often leading to increased hunger and caloric intake