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To test this hypothesis, the randomized, placebo-controlled clinical trial of sulforaphane supplementation in patients with COPD for four weeks at doses of 25 and 150 M was initiated

For instance, Long et al

Crosstalk between the LA1/TLR2 and TNF-/TNF receptor signalling pathways is mediated, at least in part, by inhibition of phosphoinositide 3-kinase (PI3K) activity at the level of IB kinase- (IKK), leading to downstream suppression of enterocyte NF-B p50/p65 signalling and consequent inhibition of MLCK gene expression

Therefore, a phased precision intervention combining low-dose inducers, ACSL4 agonists, moderate-potency GPX4 inhibitors, and low-dose liproxstatin-1 can maximize the ICD effect and enhance the efficacy of immunotherapy in gastrointestinal tumors