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Free radicals are the results of both regular aerobic metabolism and metabolic interactions with poisons, medications, and other substances

Singh AK, Mishra G, Maurya A, Awasthi R, Kumari K, Thakur A, Rai A, Rai GK, Sharma B, Kulkarni GT, Singh SK (2019) Role of TREM2 in Alzheimers disease and its consequences on - amyloid, tau and neurofibrillary tangles

Yes, prolonged heating and cooking can reduce the natural glutathione content in foods

One of the hypothesized reasons is the existence of an extra copy of amyloid precursor protein (APP) gene located on chromosome 21