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4.7.2 Increase in SCFAs enhances barrier function and mucus secretion of epithelial cells The three defense barriers of the esophageal mucosa (86), among them are the pre-epithelial barrier consisting of the mucus layer and bicarbonate, etc., and the epithelial barrier and post-epithelial barrier of the second layer of the intercellular and apical linking complexes constituting the tight junction (TJ)