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doi:10.1111/j.1651-2227.2005.tb01878.x

What community sources describe, explicitly as anecdote rather than guidance: Reports of pausing when headache, irritability, or GI symptoms persist or intensify

While effective, misuse or prolonged use can cause side effects

The oestrogenhistamine feedback loop is particularly significant for women: This self-amplifying cycle explains why histamine intolerance symptoms are consistently worse in the days before menstruation (when oestrogen is relatively elevated and progesterone is falling), around ovulation, and during perimenopause when hormonal fluctuations intensify

Innate immunity in plants: an arms race between pattern recognition receptors in plants and effectors in microbial pathogens