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101:157-166 [PMC free article: PMC4701850] [PubMed: 26580237] 226

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Identification and characterisation of glucagon-like peptide-1 receptor expressing cells using a new transgenic mouse model

Notably, discontinuation of semaglutide resulted in a rapid and sustained improvement in kidney function ( In summary, given the increasing number of case reports on GLP-1 ARs-induced renal injury ( 5 Conclusion Although semaglutide has been widely used due to its efficacy in weight reduction and glycemic control, this first systematic review of case series highlights that semaglutide-associated kidney damage is a major clinical concern

There was no apparent effect of renal impairment, hepatic impairment or upper GI disease on the PK and tolerability of orally administered semaglutide, suggesting that dose adjustment is not necessary in these special populations [11, 31,32,33]