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The PET-CT scan can be helpful in identifying other disease localizations ( Table 1 Frequency of organ involvement in IgG4-related disease ( IgG4-disease may involve the lacrimal glands, as well as the sclera, nasolacrimal duct, trigeminal nerve, extraocular muscles, orbital soft tissues, and even the optic nerve ( Renal involvement most commonly presents as tubulointerstitial nephritis (TIN), although membranous glomerulonephritis (MGN) and pyelitis may also occur ( 4.6 Cancer risk IgG4-related disease (IgG4-RD) has been increasingly recognized as a condition associated with an elevated risk of certain malignancies