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Calpain also activates the intrinsic apoptotic pathway by activating the Bcl-2 pathway (Bax/mitochondrial CytC) and activating caspase-3, which also leads to DNA fragmentation [84, 88,89,90]

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In chronic blood loss , the sustained but slower hemorrhage gradually depletes iron stores (ferritin serum iron bone marrow iron TIBC elevation hemoglobin fall), producing the classic microcytic hypochromic pattern of iron deficiency anemia (D50.0)

The nasal cavity is surprisingly complex

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