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For example, intradiscal injection of bone morphogenetic protein-2 (BMP-2) induced degenerative changes [92] and weekly intradiscal treatment with growth and differentiation factor-5 (GDF-5) or insulin-like growth factor-1 (IGF-1) resulted in inflammatory reactions in the adjacent vertebrae and connective tissue infiltrates in the NP, causing the IVD to collapse [93]

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Brooker SM, Gobeske KT, Chen J, Peng CY, Kessler JA

Cell Metab 10, 119130

A 2021 review concluded that blood draw ferritin tests may be reasonably accurate in diagnosing low iron levels