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Participant characteristics were described using mean (standard deviation) and frequencies, and compared between groups using a t-test and Chi-square test where appropriate

Potentially greater weight loss compared to monotherapy

When Yuyang Liu, a graduate student in his lab and first author of the study, compared SLC25A39's structure against others in the SLC family of transporters in the AlphaFold protein structure database, Liu spotted a unique extra loop in the protein

The RNAi construct against a firefly luciferase ( luc2 ) was used as control

However, case reports pointed to more serious outcomes like systemic toxicity, infections from injections, and even possible links to melanoma