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The agitation introduces air bubbles that create foam, and the foam-liquid interfaces generate shear stress that denatures the protein

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10.1038/362318a0 Nature 268 SomanS

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So does its dosing, as 500mg is within the ranges used in successful research on both ingredients.51 52 Also, Omres resveratrol is micronized, or decreased in particle size, a technology that has clinically yielded increased plasma resveratrol levels.53 The addition of BioPerine in the Omre formula may further improve bioavailability