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In the brain, other transporters have been observed to take up Mn into cells
It is not FDA-approved as a general obesity or cosmetic weight-loss drug
However, their protective efficacy against acetaminophen-induced acute liver failure in humans remains unsubstantiated, and such agents cannot be deemed equivalent to complete protection
Nevertheless, pharmacological levels of OXM (sufficient to activate GLP-1R and GCGR) have shown anti-obesity effects in humans, by significantly reducing appetite (108, 109) and increasing energy expenditure (110)
If you have baseline GERD, discuss it with your PlexusDx provider before starting treatment so they can recommend a slower dose ramp or concurrent antacid use
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