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A systematic review and meta-analysis of 10 randomized trials totaling 1,030 patients (Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome, Ingrosso, Ianiro, Ford and colleagues, Alimentary Pharmacology & Therapeutics , 2022) found peppermint oil superior to placebo for global IBS symptoms (number needed to treat = 4) and abdominal pain (number needed to treat = 7)

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