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In NIT-1 cells exposed to both PA and Ex-4, PPAR-KO mitigated the recovery in mitochondrial function caused by Ex-4 compared to wild type (WT) cells, indicated by an elevated ADP/ATP ratio, reduced mtDNA content, a decrease in the number of healthy mitochondria, and a lower MMP (Fig

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The recommended daily allowance for zinc is 8-11mg for adults, though slightly higher doses (15-30mg) have been used in studies examining metabolic effects

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TCF1 links GIPR signaling to the control of beta cell function and survival