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For example, gastro-oesophageal reflux disease (GORD) is listed as a common side effect (affecting up to 1 in 10 people) with semaglutide (Wegovy), while dyspepsia (indigestion) is common with several agents in this class

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Coverage often requires the following: A formal diagnosis of obesity or overweight Prior authorization approval Clinical documentation, including initial BMI and weight loss results Evidence of weight loss and exercise efforts

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The impact of defective GLP1R cell surface expression suggests that pharmacological chaperons, molecules known to facilitate proper export of proteins to the cell surface, might be of therapeutic relevance for mutation carriers, as already shown for other important metabolic receptors such as melanocortin MC4 receptor