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Long term usage was cautioned due to the occurrence of serious adverse events (SAEs) linked to eluxadoline use in 4% of the patients ( Linaclotide (Constella , Allergan Inc.) is a selective guanylate cyclase C (GC-C) agonist which is efficacious in treating constipation-predominant IBS, based on latest meta-analysis of three phase III trials specific for IBS-C (Rao et al., 2012