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We show that the heterogeneity in mitochondrial function and signalling observed across CRC samples could explain, and be used to predict, poor clinical responses in patients with locally advanced CRC

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It also means that the dose-response curve is steeper, which reinforces why accurate calculation and gradual escalation are non-negotiable

Attention has been devoted to the following variables: tumor recurrence, tumor-specific mortality, and overall mortality

Unlike stimulants, it is non-addictive and non-sedating, though long-term human data are still limited