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The timeline depends on the medication's half-lifeshorter-acting agents like liraglutide clear within days, while longer-acting options like semaglutide take approximately one week

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Step therapy can be waived with documented intolerance to phentermine, prior failure to lose weight on phentermine, or contraindication (cardiovascular disease, uncontrolled hypertension, seizure history)

437,438 This involves modulating the cell apoptosis process, for example, by decreasing the Bax/Bcl-2 ratio in cardiomyocytes, reducing cytochrome C release, and caspase activation

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