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It also promotes the downstream ATF4 to enter the nucleus and regulate the expression of UPR-reactive proteins, such as chaperones (heat shock protein (HSP))

While redox homeostasis via enhanced glutathione production is commonly associated with the normal physiological role of NRF2, collectively our results suggest that NRF2-dependent cancer cell growth does not require this enhanced glutathione production

| Eating to protect your heart on Wegovy | Staying active with cardiovascular disease | What happens to your heart if you stop Wegovy | Frequently asked questions | Take home message You can take Wegovy (semaglutide) if you have cardiovascular disease and a BMI of 27 or above, provided youre eligible, and your prescriber agrees its suitable for you

Data shown as the mean SEM