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Key points: Meal planning helps avoid anxiety around what to eat across the week Meals based on whole foods, rich in protein-focused meals Timing injections to minimise disruption to your week can be helpful Accepting hunger as a messenger, rather than a threat can be a useful approach to changing our relationship with it Building to the steady state: What to expect The good news is that the wearing-off effect typically passes after 4-8 weeks of consistent treatment as your body reaches what medical professionals call the steady state. The timeline to steady state Weeks 1-2: Most pronounced wearing-off effect, with noticeable hunger returning before each dose

[Accessed 16 September 2025] GLP-1 analogues and diabetes management

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Clinical trial data shows nausea in up to 29% of participants and fatigue in 5-7% at maintenance doses

Retatrutide is still in Phase 3 trials, with FDA approval not expected before late 2027