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Contraindications, precautions : The drug should never be taken by pregnant women, patients with early hereditary optic nerve atrophy, hypersensitivity to cyanocobalamin, hypersensitivity to cobalt

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KPV exerts its primary anti-inflammatory activity through direct intracellular penetration of immune cells and intestinal epithelial cells, where it suppresses NF-B transcription factor activity the master regulator of pro-inflammatory cytokine gene expression through a receptor-independent intracellular mechanism, resulting in downstream reduction of IL-6, IL-8, TNF-, and related inflammatory mediators

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