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Most reported side effects in practice settings are mild and often relate to administration rather than systemic effects

Also, the powdered material is more prone to conversion to the more stable (apparent) hydrate after overnight equilibration in the pH 9.3 buffer

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While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists

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