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Important safety considerations include risks of medullary thyroid carcinoma (contraindicated in patients with MEN2 or family history of MTC), pancreatitis, gallbladder disease, acute kidney injury with severe gastrointestinal adverse effects, and potential diabetic retinopathy complications in patients with type 2 diabetes

Hochner H, Friedlander Y, Calderon-Margalit R, Meiner V, Sagy Y, Avgil-Tsadok M, et al

Comparing the medications side by side for alternating decisions This comparison table helps visualize the key differences that affect alternating protocols: For a detailed comparison of how these medications stack up across additional factors, the semaglutide versus tirzepatide comparison page provides comprehensive analysis

Head-to-head data from the SURMOUNT trials showed tirzepatide producing slightly greater weight loss at equivalent treatment durations

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