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The SUSTAIN-6 cardiovascular outcomes trial identified a statistically significant increase in diabetic retinopathy complications among semaglutide-treated patients, particularly those with pre-existing retinopathy and rapid glucose reduction

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Tregs secrete immunosuppressive factors like IL-10 and transforming growth factor beta 1 (TGF-1), contributing to decreasing inflammation, supporting tissue repair, and preserving immune tolerance [143]

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