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Understanding this distinction is essential for appreciating why this combination may produce results beyond what any triple agonist alone can achieve

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In vitro evaluation of ivermectin nanoformulations The IVM nanoformulations (IVM spanlastics, IVM Se-NPs, IVM Cs-NPs, and IVM Se-Cs-NCJ, free IVM) were diluted in distilled water to obtain five different concentrations of 0.5, 0.25, 0.125, 0.0625, and 0.0313%

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NO activates soluble guanylate cyclase [174], resulting in the generation of cGMP, which in turn activates cGKI [175]