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A systematic review of semaglutide clinical trials found that while weight loss came primarily from fat mass, some trials reported lean mass reductions accounting for anywhere from almost none to roughly 40% of the total weight lost with the more notable lean mass decreases appearing in the larger trials (6)

Concurrent lifestyle changes

However, another pharmaceutical approach may be more suitable if you dont fit this profile

Wegovy is a prescription-only medication and therefore cannot be accessed or purchased without approval from a registered pharmacist or health care professional

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