Contact your healthcare provider if you notice the following symptoms: Signs of neuropathy, such as numbness, parasthesia, or a tingling sensation Persistent stomach issues Allergic reactions Tirzepatide with vitamin B12 is typically administered as a once-weekly subcutaneous injection (under the skin)
How long will it take to notice benefits
Visual inspection is your first check
Meet our doctors Last reviewed: 19 Jun 2026 Sources Effectiveness of Dulaglutide in the Real World and in Special Populations of Type 2 Diabetic Patients (2020) NIH [accessed 27 January 2026] Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial (2023) The Lancet [accessed 27 January 2026] How to use Mounjaro (2023) Mounjaro [accessed 27 January 2026] Lillys SURMONT-2 results published in The Lancet show tirzepatide achieve a mean weight reduction of 15.7% at the highest dose (15mg) in adults with obesity or overweight and type 2 diabetes (2023) Lillys INVESTORS [accessed 27 January 2026] MHRA authorised diabetes drug Mounjaro (tirzepatide) for weight management and weight loss (2023) GOV.UK
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