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However: Larger meta-analyses show no significant increase in risk after adjusting for confounders [25] Incidence appears similar to other diabetes therapies [25] Much of the observed signal likely reflects: Baseline risk (obesity, T2DM) Secondary gallstone disease In summary, pancreatitis in GLP-1 users is a rare and possible complication, but current evidence does not support a substantial increase in risk directly related to GLP-1 agents

Moreover, relatively long-lived FROP and RXS generated in the CYP-induced liver (Table 1) could aggravate pancreatic injury if they find their way there via refluxed bile (128), or the bloodstream (18)

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A population of CD34-positive cells with an unknown histogenesis is also found