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Flupirtine, a selective neuronal potassium channel opener and non-opioid analgesic, has exhibited pain relieving activity in various animal models and humans without anti-inflammatory or antipyretic properties

When mature IGF-I lacking any E-peptide extension was expressed virally, it failed to increase muscle mass, whereas the E-peptide-bearing IGF-IA and IGF-IB isoforms drove hypertrophy evidence that, in this system, the E-domain is necessary for the local anabolic effect rather than being an inert appendage

[Abstract]2025 Mar 1:351:123123

Chemotherapy-Induced Polyneuropathy Chemotherapy-induced peripheral polyneuropathy affects up to 80% of patients treated and constitutes a series adverse event, the occurrence of which may require anti-cancer therapy dose adjustment [69]