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Epac, exchange protein directly activated by cAMP

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The median preoperative BMI was 43.2 kg/m 2 (IQR 4047) with patients achieving a nadir weight of 79.6 kg (7393)

GLP-1 expression was downregulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expression of lipolysis and autophagy-related genes and proteins were also inhibited, such as adipose triacylglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and hepatic lipase deficiency gene (LIPC)