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Moreover, inhibition of PFKFB3 by 3PO has been shown to exert anti-inflammatory and antifibrotic effects on experimental lung fibrosis in mice [12]

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FDA described the clinical evidence as inconclusive and preliminary and identified product-characterisation, aggregation, immunogenicity and safety uncertainties

However, the company said the total number of events was too small to draw definitive conclusions, and the findings require further evaluation

In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin