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"Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor"
Consistent with other central nervous system injuries, microglia activation in TBI results in different phenotypes, including the pro-inflammatory M1 (neurotoxic) and anti-inflammatory M2 (neuroprotective) phenotypes (Galgano et al., 2017)
However, KEAP1 regulates multiple pathways beyond NRF2 60,82 , and the contributions of NRF2 to lipid homeostasis have been reported to be pleiotropic and context-dependent 83