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[DOI] [PMC free article] [PubMed] [Google Scholar] 232.Pearl R.L., Donze L.F., Rosas L.G., Agurs-Collins T., Baskin M.L., Breland J.Y., Byker Shanks C., Cooksey Stowers K., Johnson S., Lee B.Y., et al

Activation of GLP-1R also increases intracellular Ca 2+ through Ca 2+ release from the endoplasmic reticulum (ER) via the inositol 1,4,5 triphosphate receptors activated by PKA and the ryanodine receptors activated by Epac2 (9)

Hence, we started the present study to find out whether or not retatrutide can affect directly the mechanical function of the mammalian heart, using mouse atrial preparations as our model system

Injection site reactions, weight gain, and hypoglycemia dominate the side effect profile

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