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CHAKRABARTI: So Professor Holst, I wanted to ask you about this because there do seem to be the spectrum of intensity of side effects for these GLP-1 seems to be quite large, and the more and more people who come on it or who go on it and with staying on it for a longer period of time, are you concerned that we may start seeing side effects that are so severe that it would cast some doubt on the efficacy of GLP-1s