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A reduction in the SAM level altered the m6A modification rate and decreased the expression of PD-L1 and V-domain Ig suppressor of T-cell activation (VISTA) in cancer cells

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The lower oesophageal sphincter (LOS) consists of a 24 cm zone in the distal end of the oesophagus that has a high resting tone and, assisted by the diaphragmatic sphincter, is largely responsible for the prevention of gastric reflux

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