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& Fuchs, S
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doi: 10.1161/CIRCULATIONAHA.110.014506 5
were the first to encounter CHAC1 expression in the context of cancer cell death ( CHAC1 gene is highly upregulated in HNSC cancer after treatment with nisin which was then followed by cell death ( CHAC1 gene even though basal CHAC1 expression is significantly lower than in normal tissues ( CHAC1 upregulation after exposing HT-1080 (fibrosarcoma cell line) and Calu-1 (non-small-cell lung cancer) cells to artesunate, whereas in more recent studies, a significant increase in CHAC1 expression in Burkitts lymphoma cells was observed ( CHAC1 is upregulated by the ATF4-CHOP cascade and leads to cell death by perturbation of the redox homeostasis through changes in the ROS levels ( The pathological significance of CHAC1 and ferroptosis extends beyond cancer, having also been established in various neurological disorders
In short, giving Vitamin B12 IV needs careful thought about the dose, how its given, and whos watching over it
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