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Spatial relationships of intra-lesion heterogeneity in Mycobacterium tuberculosis microenvironment, replication status, and drug efficacy

Without interchangeability, a biosimilar requires a physician to write a new prescription or explicitly authorize substitution

Free Radic.Biol.Med 1995;18(4):823-829

Regular follow-up appointments allow healthcare professionals to assess treatment response, adjust doses, monitor for complications, and provide ongoing support for lifestyle modifications that complement pharmacological therapy

Avoid lopsided patterns like Monday and Tuesday, where a 1-day gap is followed by a 6-day gap, because that recreates the single-dose peak the split was meant to soften and then leaves a long stretch with falling levels