Phase 1: Foundation (weeks 1 through 4 on GLP-1 medication) During the initial adjustment period, keep fiber supplementation simple and conservative
Slow digestion, helping you feel full for longer
The two medications work differently, and their dosing systems are not one-to-one, which is why beginning tirzepatide at 2.5 mg is common even for those previously on high semaglutide doses
High-fibre foods such as oats, beans, lentils, and Brussels sprouts, protein-rich sources like fish, eggs, and Greek yoghurt, and healthy fats from avocados, nuts, and olive oil all stimulate natural GLP-1 secretion from intestinal L-cells
By adjusting how dopamine signals are handled, PE-22-28 may support clearer thinking and better concentration