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In Heffernan et al

HPV promotes HNSCC tumorigenesis primarily through the viral oncoproteins E6 and E7, which target and inactivate the key tumor suppressor proteins p53 and retinoblastoma protein (Rb), respectively 5

One such framework, the Value Flower, developed by the 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Special Task Force on US Value Assessments (Neumann et al., 2022), can guide new measures and data collection to quantify often overlooked elements of value, such as productivity, adherence-improving factors, reduction in uncertainty, real option value, value of hope, and scientific spillovers, among others

Journal of cardiovascular pharmacology, 82(2), 8692