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The genes involved in vivo and in vitro studies in the risk of development of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are ABCB11, ABCB4, TJP2, FXR, MYO5B, SLC51B, SLC25A13, NOTCH2, JAG1, TGR5 and HNF1B both in paediatric and non-paediatric populations [9]

For example, autosomal dominant point mutations in the -synuclein ( SNCA ) gene as well as duplication or triplication of the SNC A gene are causative for PD [221,222,223,224,225]

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