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Long-term studies are needed to validate the potential cardioprotective effects of low dose GLP-1 in generally healthy individuals A Review on the Efficacy and Safety of Oral Semaglutide PMC What the evidence suggests: Low-dose Semaglutide may reduce the rate of major cardiovascular events and death in patients with metabolic disease

Tirzepatide was developed as a unimolecular dual agonist and moved through the SURPASS (type 2 diabetes) and SURMOUNT (obesity) Phase 3 programs to approval, becoming the first approved GLP-1/GIP dual agonist

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