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Always start at the lower end of the dose range and titrate based on bowel response

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Effect of modification of hydroxyapatite/collagen composites with sodium citrate, phosphoserine, phosphoserine/RGD-peptide and calcium carbonate on bone remodelling

38 This will test whether people with obesity plus heart failure with preserved ejection fraction, randomised to tirzepatide or placebo for 52 weeks, improve a composite endpoint of mortality, heart failure events, exercise capacity, and heart failure symptoms