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Semaglutide is metabolized through protein degradation rather than hepatic metabolism, but alcohol can worsen liver disease and impair the liver's ability to regulate blood glucose
The safety profile of semaglutide has been extensively studied outside of AD and is well characterized in T2D and obesity [15, 57,58,59]
Tirzepatide is showing a similar impact but is not yet FDA approved for this indication
And insulin resistance itself, when severe enough, can blunt the metabolic improvements these medications provide
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