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Lilly's triple agonist retatrutide posts its strongest weight loss numbers yet, setting up a 2027 FDA filing Eli Lilly, this week, reported positive topline results from TRIUMPH-2 and TRIUMPH-3, two pivotal Phase 3 trials of retatrutide, a once-weekly injectable that activates receptors for GIP, GLP-1, and glucagon simultaneously a triple mechanism that no approved obesity therapy currently matches