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Among current treatments for T2D, GLP-1R agonists stand out as one of the most promising [55, 77,78,79]

Due to their remarkable ability to regulate metabolism, they have been widely adopted in the management of type 2 diabetes mellitus (T2DM) and obesity

In the current subgroup analysis of PIONEER 4, which included relatively few patients receiving both treatments, reductions in HbA 1c (of 1.11.2%) and body weight (5 kg) were similar after 1 year in patients with T2D treated with oral semaglutide with or without background SGLT2i