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Patients frequently experience: Fatigue and generalised weakness that persists despite adequate rest Breathlessness on exertion due to anaemia Palpitations and reduced exercise tolerance Pallor of the skin and mucous membranes These symptoms result from megaloblastic anaemia, where impaired DNA synthesis leads to the production of abnormally large, dysfunctional red blood cells with reduced oxygen-carrying capacity

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In support of this theory, one paper investigated the possibility of EBV-encoded proteins existing in ME/CFS, such as BRRF1 and BLLF3, and the effects they may have (129), while BLLF3 encodes a dUTPase and is expressed in the early phase of EBV lytic replication (127), EBV (127, 130, 131), and HHV-6 (130) dUTPase proteins has been identified in ME/CFS

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