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Saxagliptin did not increase the incidence of tumors in rats dosed orally at 25, 75, 150, and 300 mg/kg up to 355-times (males) and 2217-times (females) the 5 mg/day clinical dose, based on AUC

Increase gradually while we monitor effects

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When these receptors are activated by adiponectin, they cause a cascade of events that result in improved glucose metabolism, increased fat burning, and improved insulin sensitivity