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Gastroenterology 126:15931610 Borruel N, Carol M, Casellas F, Antolin M, de Lara F, Espin E, Naval J, Guarner F, Malagelada JR (2002) Increased mucosal tumour necrosis factor alpha production in Crohns disease can be downregulated ex vivo by probiotic bacteria

However, despite this localized overproduction, the total systemic burden of free radicals remains too high, leading to inevitable cellular exhaustion and highlighting the desperate need for targeted antioxidant support

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Pye SR, Huhtaniemi IT, Finn JD, Lee DM, O'Neill TW, Tajar A, Bartfai G, Boonen S, Casanueva FF, Forti G, Giwercman A, Han TS, Kula K, Lean ME, Pendleton N, Punab M, Rutter MK, Vanderschueren D, Wu FC