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Think of it like this regular glutathione is like throwing a water balloon at a brick wall
More specifically, the ARC nucleus of the hypothalamus has been highlighted as one of the main sites mediating this action as chemical lesion of the ARC in rats ablates the anorectic action of GLP-1 (Tang-Christensen et al., 1998)
For instance, a study employing mass spectrometry imaging found significant differences in metabolite distribution in the cerebellar cortex, prefrontal cortex, and hippocampus of depression model mice
It doesnt just work on the surface